منابع مشابه
Gene specific DNA repair
There is increasing interest in gene-specific repair studies. This aspect of DNA repair is currently under intense investigation and new laboratories are entering the field. The data are coming in rapidly and we are in the midst of exciting developments. Accordingly, it is premature to build extensive models of the regulation and biological importance of gene specific repair. The purpose of thi...
متن کاملOGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
متن کاملDNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملGene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro.
A large number of studies have demonstrated that various kinds of DNA damage accumulate during aging and one of the causes for this could be a decrease in DNA repair capacity. However, the level of total genomic repair has not been strongly correlated with aging. DNA repair of certain kinds of damage is known to be closely connected to the transcription process; thus, we chose to investigate th...
متن کاملGene-specific DNA repair of interstrand cross-links induced by chemotherapeutic agents can be preferential.
The gene-specific formation and repair of interstrand cross-links (ICL) were measured in the dihydrofolate reductase (DHFR) gene in hamster cells. Cells were treated with two different chemotherapeutic agents, nitrogen mustard and cisplatin, and the frequency of cross-links was quantified in the active gene and in a downstream, inactive region. About 5% of total lesions induced by these agents ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1991
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/12.11.1983